Foda na Proline
Proline (an takaita shi azaman Pro ko P), tare da dabarar sinadarai ta C5H9NO2 da nauyin kwayoyin halitta na 115.13, wani sinadari ne mai siffar cyclic sub amino acid. α- Amino acid, tsaka tsaki, tare da ma'aunin isoelectric na 6.30, yana da mafi yawan narkewa a cikin ruwa fiye da kowane amino acid, kuma yana iya narkewa kusan 162g a cikin 100g na ruwa a 25 ℃. Mai sauƙin narkewa amma ba mai sauƙin lulluɓewa ba, tare da ɗanɗano mai daɗi. Dumamawa tare da maganin ninhydrin yana haifar da mahaɗan rawaya. Da zarar ya shiga sarkar peptide, hydroxylation na iya faruwa, wanda ke haifar da samuwar 4-hydroxyproline, wanda muhimmin sashi ne na collagen na dabbobi. Hydroxyproline kuma yana nan a cikin furotin iri-iri na shuka, musamman ma da alaƙa da samuwar bangon tantanin halitta. Tsire-tsire galibi suna fuskantar tarin proline mai yawa a ƙarƙashin yanayi daban-daban masu wahala kamar fari, zafi mai yawa, ƙarancin zafin jiki, da gishiri. Ana amfani da shi sosai a fannin asibiti, kayan halitta, masana'antu, da sauran fannoni.
Akwai nau'ikan proline guda uku:DL proline, L-proline, da D-proline. Wanda aka fi sani da proline shine L-proline, wani amino acid da ke faruwa ta halitta. A zafin jiki na ɗaki, wannan samfurin lu'ulu'u ne mai siffar ginshiƙi. Da sauri ya ruɓe idan aka dumama shi zuwa 215-220 ℃. Yana narkewa a cikin ruwan zafi da ethanol. Yana da ɗan daɗi da hygroscopic. Racemization a cikin maganin alkaline. [α] D25-86.5 ° (ruwa), -60.4 ° (5N hydrochloric acid). An rarraba shi a cikin furotin daban-daban. Amino acid mai matsakaicin abun ciki a cikin marine plankton; Hakanan yana wanzuwa a cikin ruwan teku, ƙwayoyin cuta, da laka na ruwa.
Proline amino acid ne wanda ba shi da mahimmanci a jikin ɗan adam.
Aiki da manufa
Aikace-aikace a cikin masana'antar magunguna
Magungunan amino acid. Ɗaya daga cikin kayan da ake amfani da su wajen haɗa amino acid. Ana amfani da su don ƙara yawan furotin bayan rashin abinci mai gina jiki, ƙarancin furotin, cututtukan hanji masu tsanani, ƙonewa, da kuma tiyata. Babu wata illa mai guba da ke bayyana.
Tasirin cikin jiki
A cikin halittu masu rai, proline ba wai kawai wani abu ne mai kyau na osmoregulation ba, har ma yana aiki a matsayin abu mai kariya ga membranes da enzymes, da kuma mai tsabtace ƙwayoyin halitta, wanda hakan ke kare ci gaban tsirrai a ƙarƙashin matsin lamba na osmotic. Don tara wani muhimmin abu na osmoregulation a cikin vacuoles a cikin halittu masu rai na potassium ion, proline kuma yana iya taka rawa wajen daidaita ma'aunin osmotic na cytoplasmic.
Aikace-aikacen masana'antu
A cikin masana'antar haɗakar sinadarai, proline na iya shiga cikin haifar da halayen da ba su da alaƙa da juna kuma yana aiki a matsayin mai haɓaka hydrogenation, polymerization, da halayen da ke shiga tsakani a cikin ruwa. Idan aka yi amfani da shi azaman mai haɓaka irin waɗannan halayen, yana da ƙarfi da aiki mai kyau da kuma kyakkyawan yanayin stereospecificity.
Aikace-aikace a wasu fannoni
1. Ana amfani da Proline da abubuwan da aka samo daga gare shi a matsayin abubuwan da ke ƙara yawan haɗuwa a cikin halayen halitta, tare da raguwar CBS da kuma amsawar catalytic aldol condensation na proline a matsayin misalai masu kyau.
2. A lokacin yin giya, furotin yana da wadataccen sinadarin proline wanda ke ɗaure da polyphenols, wanda zai iya haifar da hazo (turbidity).
3. Kayan da aka samar don haɗa magungunan hana ester na gallstone.
4. Sinadaran dandano, waɗanda ke amsawa da sukari ta hanyar dumama co don samar da amino hydrogen groups, na iya samar da abubuwa masu ƙamshi na musamman.
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